FBXW8-CDK17 Fusion FISH Probe
The FBXW8-CDK17 Fusion FISH Probe is used to confirm a fusion of the FBXW8 and CDK17 genes. The fusion of the FBXW8 and CDK17 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXW8-CDK17-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-RERE | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-REOR | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-REGO | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-REGR | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-OROR | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-GORE | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-GROR | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXW8-CDK17-20-AQAQ | 20 (40 μL) | 200 μL |
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CDK17 Gene Summary
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Gene Name: Cyclin Dependent Kinase 17
Chromosome: CHR12: 96672038 -96794366
Locus: 12q23.1
FBXW8 Gene Summary
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: F-box And WD Repeat Domain Containing 8
Chromosome: CHR12: 117348760 -117468953
Locus: 12q24.22
Gene Diseases
The FBXW8 CDK17 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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