FBXW7-TMEM154 Fusion FISH Probe
The FBXW7-TMEM154 Fusion FISH Probe is used to confirm a fusion of the FBXW7 and TMEM154 genes. The fusion of the FBXW7 and TMEM154 genes has been associated with Lung Squamous Cell Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXW7-TMEM154-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-RERE | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-REOR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-REGO | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-REGR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-OROR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-GORE | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-GROR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM154-20-AQAQ | 20 (40 μL) | 200 μL |
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FBXW7 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Name: F-box And WD Repeat Domain Containing 7
Chromosome: CHR4: 153242409 -153456172
Locus: 4q31.3
TMEM154 Gene Summary
The Transmembrane Protein 154 (TMEM154) gene is located on chr4 :153547265-153601317 at 4q31.3.
Gene Name: Transmembrane Protein 154
Chromosome: CHR4: 153547265 -153601317
Locus: 4q31.3
Gene Diseases
The FBXW7 TMEM154 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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