FBXW7-TMEM126B Fusion FISH Probe
The FBXW7-TMEM126B Fusion FISH Probe is used to confirm a fusion of the FBXW7 and TMEM126B genes. The fusion of the FBXW7 and TMEM126B genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXW7-TMEM126B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-RERE | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-REOR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-REGO | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-REGR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-OROR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-GORE | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-GROR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXW7-TMEM126B-20-AQAQ | 20 (40 μL) | 200 μL |
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FBXW7 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Name: F-box And WD Repeat Domain Containing 7
Chromosome: CHR4: 153242409 -153456172
Locus: 4q31.3
TMEM126B Gene Summary
This gene encodes a mitochondrial transmembrane protein which is a component of the mitochondrial complex I assembly complex. The encoded protein serves as an assembly factor that is required for formation of the membrane arm of the complex. It interacts with NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 13. Naturally occurring mutations in this gene are associated with isolated complex I deficiency. A pseudogene of this gene has been defined on chromosome 9. [provided by RefSeq, Apr 2017]
Gene Name: Transmembrane Protein 126B
Chromosome: CHR11: 85339621 -85347583
Locus: 11q14.1
Gene Diseases
The FBXW7 TMEM126B Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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