FBXW7-SH3D19 Fusion FISH Probe
The FBXW7-SH3D19 Fusion FISH Probe is used to confirm a fusion of the FBXW7 and SH3D19 genes. The fusion of the FBXW7 and SH3D19 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXW7-SH3D19-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-RERE | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-REOR | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-REGO | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-REGR | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-OROR | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-GORE | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-GROR | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXW7-SH3D19-20-AQAQ | 20 (40 μL) | 200 μL |
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FBXW7 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Name: F-box And WD Repeat Domain Containing 7
Chromosome: CHR4: 153242409 -153456172
Locus: 4q31.3
SH3D19 Gene Summary
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: SH3 Domain Containing 19
Chromosome: CHR4: 152041432 -152149182
Locus: 4q31.3
Gene Diseases
The FBXW7 SH3D19 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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