FBXW4-C10ORF76 Fusion FISH Probe
The FBXW4-C10ORF76 Fusion FISH Probe is used to confirm a fusion of the FBXW4 and C10ORF76 genes. The fusion of the FBXW4 and C10ORF76 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXW4-C10ORF76-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-RERE | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-REOR | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-REGO | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-REGR | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-OROR | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-GORE | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-GROR | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXW4-C10ORF76-20-AQAQ | 20 (40 μL) | 200 μL |
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FBXW4 Gene Summary
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008]
Gene Name: F-box And WD Repeat Domain Containing 4
Chromosome: CHR10: 103370420 -103454743
Locus: 10q24.32
C10orf76 Gene Summary
The Chromosome 10 Open Reading Frame 76 (C10orf76) gene is located on chr10 :103605355-103815932 at 10q24.32.
Gene Name: Chromosome 10 Open Reading Frame 76
Chromosome: CHR10: 103605355 -103815932
Locus: 10q24.32
Gene Diseases
The FBXW4 C10ORF76 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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