FBXW2-NXNL2 Fusion FISH Probe
The FBXW2-NXNL2 Fusion FISH Probe is used to confirm a fusion of the FBXW2 and NXNL2 genes. The fusion of the FBXW2 and NXNL2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FBXW2-NXNL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| FBXW2-NXNL2-20-AQAQ | 20 (40 μL) | 200 μL |
|
FBXW2 Gene Summary
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
Gene Name: F-box And WD Repeat Domain Containing 2
Chromosome: CHR9: 123519253 -123555740
Locus: 9q33.2
NXNL2 Gene Summary
The Nucleoredoxin Like 2 (NXNL2) gene is located on chr9 :91150015-91190704 at 9q22.1.
Gene Name: Nucleoredoxin Like 2
Chromosome: CHR9: 91150015 -91190704
Locus: 9q22.1
Gene Diseases
The FBXW2 NXNL2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|