FBXW11-KCNIP1 Fusion FISH Probe
The FBXW11-KCNIP1 Fusion FISH Probe is used to confirm a fusion of the FBXW11 and KCNIP1 genes. The fusion of the FBXW11 and KCNIP1 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXW11-KCNIP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-RERE | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-REOR | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-REGO | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-REGR | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-OROR | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-GORE | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-GROR | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXW11-KCNIP1-20-AQAQ | 20 (40 μL) | 200 μL |
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FBXW11 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]
Gene Name: F-box And WD Repeat Domain Containing 11
Chromosome: CHR5: 171288555 -171433877
Locus: 5q35.1
KCNIP1 Gene Summary
This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Gene Name: Potassium Voltage-gated Channel Interacting Protein 1
Chromosome: CHR5: 169780880 -170163636
Locus: 5q35.1
Gene Diseases
The FBXW11 KCNIP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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