FBXO8-PALLD Fusion FISH Probe
The FBXO8-PALLD Fusion FISH Probe is used to confirm a fusion of the FBXO8 and PALLD genes. The fusion of the FBXO8 and PALLD genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXO8-PALLD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-RERE | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-REOR | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-REGO | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-REGR | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-OROR | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-GORE | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-GROR | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXO8-PALLD-20-AQAQ | 20 (40 μL) | 200 μL |
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PALLD Gene Summary
This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Name: Palladin, Cytoskeletal Associated Protein
Chromosome: CHR4: 169418216 -169849608
Locus: 4q32.3
FBXO8 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]
Gene Name: F-box Protein 8
Chromosome: CHR4: 175157809 -175205402
Locus: 4q34.1
Gene Diseases
The FBXO8 PALLD Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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