FBXO46-SYMPK Fusion FISH Probe
The FBXO46-SYMPK Fusion FISH Probe is used to confirm a fusion of the FBXO46 and SYMPK genes. The fusion of the FBXO46 and SYMPK genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXO46-SYMPK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-RERE | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-REOR | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-REGO | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-REGR | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-OROR | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-GORE | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-GROR | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXO46-SYMPK-20-AQAQ | 20 (40 μL) | 200 μL |
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SYMPK Gene Summary
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
Gene Name: Symplekin
Chromosome: CHR19: 46318699 -46366548
Locus: 19q13.32
FBXO46 Gene Summary
Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Name: F-box Protein 46
Chromosome: CHR19: 46213886 -46234151
Locus: 19q13.32
Gene Diseases
The FBXO46 SYMPK Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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