FBXO46-ARG2 Fusion FISH Probe
The FBXO46-ARG2 Fusion FISH Probe is used to confirm a fusion of the FBXO46 and ARG2 genes. The fusion of the FBXO46 and ARG2 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXO46-ARG2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-RERE | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-REOR | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-REGO | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-REGR | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-OROR | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-GORE | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-GROR | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXO46-ARG2-20-AQAQ | 20 (40 μL) | 200 μL |
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ARG2 Gene Summary
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
Gene Name: Arginase 2
Chromosome: CHR14: 68086578 -68118436
Locus: 14q24.1
FBXO46 Gene Summary
Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Name: F-box Protein 46
Chromosome: CHR19: 46213886 -46234151
Locus: 19q13.32
Gene Diseases
The FBXO46 ARG2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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