FBXO42-RUNX1 Fusion FISH Probe
The FBXO42-RUNX1 Fusion FISH Probe is used to confirm a fusion of the FBXO42 and RUNX1 genes. The fusion of the FBXO42 and RUNX1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXO42-RUNX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-RERE | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-REOR | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-REGO | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-REGR | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-OROR | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-GORE | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-GROR | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXO42-RUNX1-20-AQAQ | 20 (40 μL) | 200 μL |
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RUNX1 Gene Summary
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Runt Related Transcription Factor 1
Chromosome: CHR21: 36160097 -36421595
Locus: 21q22.12
FBXO42 Gene Summary
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]
Gene Name: F-box Protein 42
Chromosome: CHR1: 16576558 -16678948
Locus: 1p36.13
Gene Diseases
The FBXO42 RUNX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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