FBXO34-LGALS3 Fusion FISH Probe
The FBXO34-LGALS3 Fusion FISH Probe is used to confirm a fusion of the FBXO34 and LGALS3 genes. The fusion of the FBXO34 and LGALS3 genes has been associated with Lung Adenocarcinoma, and Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXO34-LGALS3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-RERE | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-REOR | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-REGO | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-REGR | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-OROR | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-GORE | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-GROR | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXO34-LGALS3-20-AQAQ | 20 (40 μL) | 200 μL |
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LGALS3 Gene Summary
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]
Gene Name: Galectin 3
Chromosome: CHR14: 55595934 -55612148
Locus: 14q22.3
FBXO34 Gene Summary
Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Name: F-box Protein 34
Chromosome: CHR14: 55738020 -55820329
Locus: 14q22.3
Gene Diseases
The FBXO34 LGALS3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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