FBXO22-SNX33 Fusion FISH Probe
The FBXO22-SNX33 Fusion FISH Probe is used to confirm a fusion of the FBXO22 and SNX33 genes. The fusion of the FBXO22 and SNX33 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXO22-SNX33-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-RERE | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-REOR | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-REGO | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-REGR | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-OROR | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-GORE | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-GROR | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXO22-SNX33-20-AQAQ | 20 (40 μL) | 200 μL |
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FBXO22 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Name: F-box Protein 22
Chromosome: CHR15: 76196199 -76227608
Locus: 15q24.2
SNX33 Gene Summary
The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Name: Sorting Nexin 33
Chromosome: CHR15: 75941347 -75950968
Locus: 15q24.2
Gene Diseases
The FBXO22 SNX33 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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