FBXO18-ITGA8 Fusion FISH Probe
The FBXO18-ITGA8 Fusion FISH Probe is used to confirm a fusion of the FBXO18 and ITGA8 genes. The fusion of the FBXO18 and ITGA8 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXO18-ITGA8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-RERE | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-REOR | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-REGO | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-REGR | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-OROR | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-GORE | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-GROR | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXO18-ITGA8-20-AQAQ | 20 (40 μL) | 200 μL |
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ITGA8 Gene Summary
Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]
Gene Name: Integrin Subunit Alpha 8
Chromosome: CHR10: 15559087 -15761770
Locus: 10p13
FBXO18 Gene Summary
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: F-box Protein, Helicase, 18
Chromosome: CHR10: 5932213 -5979556
Locus: 10p15.1
Gene Diseases
The FBXO18 ITGA8 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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