FBXO18-FRMD4A Fusion FISH Probe
The FBXO18-FRMD4A Fusion FISH Probe is used to confirm a fusion of the FBXO18 and FRMD4A genes. The fusion of the FBXO18 and FRMD4A genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXO18-FRMD4A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-RERE | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-REOR | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-REGO | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-REGR | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-OROR | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-GORE | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-GROR | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXO18-FRMD4A-20-AQAQ | 20 (40 μL) | 200 μL |
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FRMD4A Gene Summary
This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: FERM Domain Containing 4A
Chromosome: CHR10: 13685705 -14372866
Locus: 10p13
FBXO18 Gene Summary
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: F-box Protein, Helicase, 18
Chromosome: CHR10: 5932213 -5979556
Locus: 10p15.1
Gene Diseases
The FBXO18 FRMD4A Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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