FBXO11-INTS9 Fusion FISH Probe
The FBXO11-INTS9 Fusion FISH Probe is used to confirm a fusion of the FBXO11 and INTS9 genes. The fusion of the FBXO11 and INTS9 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXO11-INTS9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-RERE | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-REOR | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-REGO | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-REGR | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-OROR | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-GORE | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-GROR | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXO11-INTS9-20-AQAQ | 20 (40 μL) | 200 μL |
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INTS9 Gene Summary
This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Gene Name: Integrator Complex Subunit 9
Chromosome: CHR8: 28625174 -28747698
Locus: 8p21.1
FBXO11 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Gene Name: F-box Protein 11
Chromosome: CHR2: 48034058 -48132932
Locus: 2p16.3
Gene Diseases
The FBXO11 INTS9 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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