FBXL7-CDH10 Fusion FISH Probe
The FBXL7-CDH10 Fusion FISH Probe is used to confirm a fusion of the FBXL7 and CDH10 genes. The fusion of the FBXL7 and CDH10 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXL7-CDH10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-RERE | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-REOR | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-REGO | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-REGR | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-OROR | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-GORE | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-GROR | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXL7-CDH10-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH10 Gene Summary
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 10
Chromosome: CHR5: 24487208 -24645085
Locus: 5p14.2-p14.1
FBXL7 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Name: F-box And Leucine Rich Repeat Protein 7
Chromosome: CHR5: 15500304 -15939900
Locus: 5p15.1
Gene Diseases
The FBXL7 CDH10 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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