FBXL3-MYCBP2 Fusion FISH Probe
The FBXL3-MYCBP2 Fusion FISH Probe is used to confirm a fusion of the FBXL3 and MYCBP2 genes. The fusion of the FBXL3 and MYCBP2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXL3-MYCBP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-RERE | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-REOR | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-REGO | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-REGR | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-OROR | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-GORE | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-GROR | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXL3-MYCBP2-20-AQAQ | 20 (40 μL) | 200 μL |
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MYCBP2 Gene Summary
This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]
Gene Name: MYC Binding Protein 2, E3 Ubiquitin Protein Ligase
Chromosome: CHR13: 77618791 -77901177
Locus: 13q22.3
FBXL3 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]
Gene Name: F-box And Leucine Rich Repeat Protein 3
Chromosome: CHR13: 77579388 -77601331
Locus: 13q22.3
Gene Diseases
The FBXL3 MYCBP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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