FBXL3-KLF5 Fusion FISH Probe
The FBXL3-KLF5 Fusion FISH Probe is used to confirm a fusion of the FBXL3 and KLF5 genes. The fusion of the FBXL3 and KLF5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXL3-KLF5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-RERE | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-REOR | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-REGO | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-REGR | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-OROR | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-GORE | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-GROR | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXL3-KLF5-20-AQAQ | 20 (40 μL) | 200 μL |
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KLF5 Gene Summary
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: Kruppel Like Factor 5
Chromosome: CHR13: 73633141 -73651676
Locus: 13q22.1
FBXL3 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]
Gene Name: F-box And Leucine Rich Repeat Protein 3
Chromosome: CHR13: 77579388 -77601331
Locus: 13q22.3
Gene Diseases
The FBXL3 KLF5 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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