FBXL20-UVRAG Fusion FISH Probe
The FBXL20-UVRAG Fusion FISH Probe is used to confirm a fusion of the FBXL20 and UVRAG genes. The fusion of the FBXL20 and UVRAG genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FBXL20-UVRAG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-RERE | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-REOR | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-REGO | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-REGR | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-OROR | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-GORE | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-GROR | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| FBXL20-UVRAG-20-AQAQ | 20 (40 μL) | 200 μL |
|
UVRAG Gene Summary
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Name: UV Radiation Resistance Associated
Chromosome: CHR11: 75526211 -75855282
Locus: 11q13.5
FBXL20 Gene Summary
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Name: F-box And Leucine Rich Repeat Protein 20
Chromosome: CHR17: 37408896 -37557909
Locus: 17q12
Gene Diseases
The FBXL20 UVRAG Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|