FBXL20-NOTCH2 Fusion FISH Probe
The FBXL20-NOTCH2 Fusion FISH Probe is used to confirm a fusion of the FBXL20 and NOTCH2 genes. The fusion of the FBXL20 and NOTCH2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXL20-NOTCH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-RERE | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-REOR | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-REGO | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-REGR | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-OROR | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-GORE | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-GROR | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXL20-NOTCH2-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH2 Gene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Notch 2
Chromosome: CHR1: 120454175 -120612317
Locus: 1p12
FBXL20 Gene Summary
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Name: F-box And Leucine Rich Repeat Protein 20
Chromosome: CHR17: 37408896 -37557909
Locus: 17q12
Gene Diseases
The FBXL20 NOTCH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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