FBXL20-BTBD1 Fusion FISH Probe
The FBXL20-BTBD1 Fusion FISH Probe is used to confirm a fusion of the FBXL20 and BTBD1 genes. The fusion of the FBXL20 and BTBD1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXL20-BTBD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-RERE | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-REOR | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-REGO | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-REGR | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-OROR | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-GORE | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-GROR | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXL20-BTBD1-20-AQAQ | 20 (40 μL) | 200 μL |
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BTBD1 Gene Summary
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: BTB Domain Containing 1
Chromosome: CHR15: 83685180 -83736106
Locus: 15q25.2
FBXL20 Gene Summary
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Name: F-box And Leucine Rich Repeat Protein 20
Chromosome: CHR17: 37408896 -37557909
Locus: 17q12
Gene Diseases
The FBXL20 BTBD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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