FBXL19-RNF40 Fusion FISH Probe
The FBXL19-RNF40 Fusion FISH Probe is used to confirm a fusion of the FBXL19 and RNF40 genes. The fusion of the FBXL19 and RNF40 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBXL19-RNF40-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-RERE | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-REOR | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-REGO | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-REGR | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-REAQ | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-ORRE | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-OROR | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-ORGO | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-GORE | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-GOOR | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-GOGO | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-GOGR | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-GRRE | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-GROR | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-GRGO | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-GRGR | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-AQRE | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-AQOR | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-AQGO | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-AQGR | 20 (40 μL) | 200 μL |
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| FBXL19-RNF40-20-AQAQ | 20 (40 μL) | 200 μL |
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RNF40 Gene Summary
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Name: Ring Finger Protein 40
Chromosome: CHR16: 30772932 -30787628
Locus: 16p11.2
FBXL19 Gene Summary
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Name: F-box And Leucine Rich Repeat Protein 19
Chromosome: CHR16: 30935895 -30960104
Locus: 16p11.2
Gene Diseases
The FBXL19 RNF40 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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