FBLIM1-CELA2B Fusion FISH Probe
The FBLIM1-CELA2B Fusion FISH Probe is used to confirm a fusion of the FBLIM1 and CELA2B genes. The fusion of the FBLIM1 and CELA2B genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBLIM1-CELA2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-RERE | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-REOR | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-REGO | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-REGR | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-REAQ | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-ORRE | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-OROR | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-ORGO | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-GORE | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-GOOR | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-GOGO | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-GOGR | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-GRRE | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-GROR | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-GRGO | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-GRGR | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-AQRE | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-AQOR | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-AQGO | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-AQGR | 20 (40 μL) | 200 μL |
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| FBLIM1-CELA2B-20-AQAQ | 20 (40 μL) | 200 μL |
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CELA2B Gene Summary
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, Jul 2008]
Gene Name: Chymotrypsin Like Elastase Family Member 2B
Chromosome: CHR1: 15802595 -15817895
Locus: 1p36.21
FBLIM1 Gene Summary
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Filamin Binding LIM Protein 1
Chromosome: CHR1: 16085254 -16113084
Locus: 1p36.21
Gene Diseases
The FBLIM1 CELA2B Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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