FBL-RYR1 Fusion FISH Probe
The FBL-RYR1 Fusion FISH Probe is used to confirm a fusion of the FBL and RYR1 genes. The fusion of the FBL and RYR1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBL-RYR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-RERE | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-REOR | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-REGO | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-REGR | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-REAQ | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-ORRE | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-OROR | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-ORGO | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-GORE | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-GOOR | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-GOGO | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-GOGR | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-GRRE | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-GROR | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-GRGO | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-GRGR | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-AQRE | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-AQOR | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-AQGO | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-AQGR | 20 (40 μL) | 200 μL |
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| FBL-RYR1-20-AQAQ | 20 (40 μL) | 200 μL |
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FBL Gene Summary
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
Gene Name: Fibrillarin
Chromosome: CHR19: 40325092 -40337054
Locus: 19q13.2
RYR1 Gene Summary
This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Ryanodine Receptor 1
Chromosome: CHR19: 38924339 -39078204
Locus: 19q13.2
Gene Diseases
The FBL RYR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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