FBL-RASGRP4 Fusion FISH Probe
The FBL-RASGRP4 Fusion FISH Probe is used to confirm a fusion of the FBL and RASGRP4 genes. The fusion of the FBL and RASGRP4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FBL-RASGRP4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-RERE | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-REOR | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-REGO | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-REGR | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-REAQ | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-ORRE | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-OROR | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-ORGO | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-ORAQ | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-GORE | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-GOOR | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-GOGO | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-GOGR | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-GOAQ | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-GRRE | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-GROR | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-GRGO | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-GRGR | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-GRAQ | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-AQRE | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-AQOR | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-AQGO | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-AQGR | 20 (40 μL) | 200 μL |
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| FBL-RASGRP4-20-AQAQ | 20 (40 μL) | 200 μL |
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FBL Gene Summary
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
Gene Name: Fibrillarin
Chromosome: CHR19: 40325092 -40337054
Locus: 19q13.2
RASGRP4 Gene Summary
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Gene Name: RAS Guanyl Releasing Protein 4
Chromosome: CHR19: 38899697 -38916945
Locus: 19q13.2
Gene Diseases
The FBL RASGRP4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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