FAT2-ATOX1 Fusion FISH Probe
The FAT2-ATOX1 Fusion FISH Probe is used to confirm a fusion of the FAT2 and ATOX1 genes. The fusion of the FAT2 and ATOX1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FAT2-ATOX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-RERE | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-REOR | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-REGO | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-REGR | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-REAQ | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-ORRE | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-OROR | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-ORGO | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-GORE | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-GOOR | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-GOGO | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-GOGR | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-GRRE | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-GROR | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-GRGO | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-GRGR | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-AQRE | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-AQOR | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-AQGO | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-AQGR | 20 (40 μL) | 200 μL |
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| FAT2-ATOX1-20-AQAQ | 20 (40 μL) | 200 μL |
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ATOX1 Gene Summary
This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
Gene Name: Antioxidant 1 Copper Chaperone
Chromosome: CHR5: 151122382 -151138210
Locus: 5q33.1
FAT2 Gene Summary
This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]
Gene Name: FAT Atypical Cadherin 2
Chromosome: CHR5: 150883652 -150948505
Locus: 5q33.1
Gene Diseases
The FAT2 ATOX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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