FAT1-STAT6 Fusion FISH Probe
The FAT1-STAT6 Fusion FISH Probe is used to confirm a fusion of the FAT1 and STAT6 genes. The fusion of the FAT1 and STAT6 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FAT1-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| FAT1-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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FAT1 Gene Summary
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
Gene Name: FAT Atypical Cadherin 1
Chromosome: CHR4: 187508936 -187644987
Locus: 4q35.2
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The FAT1 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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