FAT1-NTRK3 Fusion FISH Probe
The FAT1-NTRK3 Fusion FISH Probe is used to confirm a fusion of the FAT1 and NTRK3 genes. The fusion of the FAT1 and NTRK3 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FAT1-NTRK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-RERE | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-REOR | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-REGO | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-REGR | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-REAQ | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-ORRE | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-OROR | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-ORGO | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-GORE | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-GOOR | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-GOGO | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-GOGR | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-GRRE | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-GROR | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-GRGO | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-GRGR | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-AQRE | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-AQOR | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-AQGO | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-AQGR | 20 (40 μL) | 200 μL |
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| FAT1-NTRK3-20-AQAQ | 20 (40 μL) | 200 μL |
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FAT1 Gene Summary
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
Gene Name: FAT Atypical Cadherin 1
Chromosome: CHR4: 187508936 -187644987
Locus: 4q35.2
NTRK3 Gene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Name: Neurotrophic Receptor Tyrosine Kinase 3
Chromosome: CHR15: 88419987 -88799962
Locus: 15q25.3
Gene Diseases
The FAT1 NTRK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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