FAT1-NPY1R Fusion FISH Probe
The FAT1-NPY1R Fusion FISH Probe is used to confirm a fusion of the FAT1 and NPY1R genes. The fusion of the FAT1 and NPY1R genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FAT1-NPY1R-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-RERE | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-REOR | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-REGO | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-REGR | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-REAQ | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-ORRE | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-OROR | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-ORGO | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-ORAQ | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-GORE | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-GOOR | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-GOGO | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-GOGR | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-GOAQ | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-GRRE | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-GROR | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-GRGO | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-GRGR | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-GRAQ | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-AQRE | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-AQOR | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-AQGO | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-AQGR | 20 (40 μL) | 200 μL |
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| FAT1-NPY1R-20-AQAQ | 20 (40 μL) | 200 μL |
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FAT1 Gene Summary
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
Gene Name: FAT Atypical Cadherin 1
Chromosome: CHR4: 187508936 -187644987
Locus: 4q35.2
NPY1R Gene Summary
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Gene Name: Neuropeptide Y Receptor Y1
Chromosome: CHR4: 164245116 -164253947
Locus: 4q32.2
Gene Diseases
The FAT1 NPY1R Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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