FAT1-IRF2 Fusion FISH Probe
The FAT1-IRF2 Fusion FISH Probe is used to confirm a fusion of the FAT1 and IRF2 genes. The fusion of the FAT1 and IRF2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FAT1-IRF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-RERE | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-REOR | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-REGO | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-REGR | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-REAQ | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-ORRE | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-OROR | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-ORGO | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-GORE | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-GOOR | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-GOGO | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-GOGR | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-GRRE | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-GROR | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-GRGO | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-GRGR | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-AQRE | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-AQOR | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-AQGO | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-AQGR | 20 (40 μL) | 200 μL |
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| FAT1-IRF2-20-AQAQ | 20 (40 μL) | 200 μL |
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FAT1 Gene Summary
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
Gene Name: FAT Atypical Cadherin 1
Chromosome: CHR4: 187508936 -187644987
Locus: 4q35.2
IRF2 Gene Summary
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
Gene Name: Interferon Regulatory Factor 2
Chromosome: CHR4: 185308875 -185395726
Locus: 4q35.1
Gene Diseases
The FAT1 IRF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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