FAS-CTNND2 Fusion FISH Probe
The FAS-CTNND2 Fusion FISH Probe is used to confirm a fusion of the FAS and CTNND2 genes. The fusion of the FAS and CTNND2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FAS-CTNND2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-RERE | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-REOR | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-REGO | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-REGR | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-REAQ | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-ORRE | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-OROR | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-ORGO | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-ORAQ | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-GORE | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-GOOR | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-GOGO | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-GOGR | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-GOAQ | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-GRRE | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-GROR | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-GRGO | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-GRGR | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-GRAQ | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-AQRE | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-AQOR | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-AQGO | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-AQGR | 20 (40 μL) | 200 μL |
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| FAS-CTNND2-20-AQAQ | 20 (40 μL) | 200 μL |
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FAS Gene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
Gene Name: Fas Cell Surface Death Receptor
Chromosome: CHR10: 90750287 -90775542
Locus: 10q23.31
CTNND2 Gene Summary
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Gene Name: Catenin Delta 2
Chromosome: CHR5: 10971951 -11904110
Locus: 5p15.2
Gene Diseases
The FAS CTNND2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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