FARP1-NALCN Fusion FISH Probe
The FARP1-NALCN Fusion FISH Probe is used to confirm a fusion of the FARP1 and NALCN genes. The fusion of the FARP1 and NALCN genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FARP1-NALCN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-RERE | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-REOR | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-REGO | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-REGR | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-REAQ | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-ORRE | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-OROR | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-ORGO | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-ORAQ | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-GORE | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-GOOR | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-GOGO | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-GOGR | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-GOAQ | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-GRRE | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-GROR | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-GRGO | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-GRGR | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-GRAQ | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-AQRE | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-AQOR | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-AQGO | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-AQGR | 20 (40 μL) | 200 μL |
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| FARP1-NALCN-20-AQAQ | 20 (40 μL) | 200 μL |
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FARP1 Gene Summary
This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: FERM, ARH/RhoGEF And Pleckstrin Domain Protein 1
Chromosome: CHR13: 98795433 -99102023
Locus: 13q32.2
NALCN Gene Summary
This gene encodes a voltage-independent, nonselective cation channel which belongs to a family of voltage-gated sodium and calcium channels that regulates the resting membrane potential and excitability of neurons. This family is expressed throughout the nervous system and conducts a persistent sodium leak current that contributes to tonic neuronal excitability. The encoded protein forms a channelosome complex that includes G-protein-coupled receptors, UNC-79, UNC-80, NCA localization factor-1, and src family tyrosine kinases. Naturally occurring mutations in this gene are associated with infantile neuroaxonal dystrophy, infantile hypotonia with psychomotor retardation and characteristic facies (IHPRF) syndrome, and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD) syndrome. A knockout of the orthologous gene in mice results in paralysis with a severely disrupted respiratory rhythm, and lethality within 24 hours after birth. [provided by RefSeq, Apr 2017]
Gene Name: Sodium Leak Channel, Non-selective
Chromosome: CHR13: 101706129 -102068813
Locus: 13q32.3-q33.1
Gene Diseases
The FARP1 NALCN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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