FANCA-CACNA2D4 Fusion FISH Probe
The FANCA-CACNA2D4 Fusion FISH Probe is used to confirm a fusion of the FANCA and CACNA2D4 genes. The fusion of the FANCA and CACNA2D4 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FANCA-CACNA2D4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-RERE | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-REOR | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-REGO | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-REGR | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-REAQ | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-ORRE | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-OROR | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-ORGO | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-ORAQ | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-GORE | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-GOOR | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-GOGO | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-GOGR | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-GOAQ | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-GRRE | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-GROR | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-GRGO | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-GRGR | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-GRAQ | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-AQRE | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-AQOR | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-AQGO | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-AQGR | 20 (40 μL) | 200 μL |
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| FANCA-CACNA2D4-20-AQAQ | 20 (40 μL) | 200 μL |
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FANCA Gene Summary
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008]
Gene Name: Fanconi Anemia Complementation Group A
Chromosome: CHR16: 89803958 -89883065
Locus: 16q24.3
CACNA2D4 Gene Summary
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Calcium Voltage-gated Channel Auxiliary Subunit Alpha2delta 4
Chromosome: CHR12: 1901122 -2027870
Locus: 12p13.33
Gene Diseases
The FANCA CACNA2D4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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