FAM49B-PREX2 Fusion FISH Probe
The FAM49B-PREX2 Fusion FISH Probe is used to confirm a fusion of the FAM49B and PREX2 genes. The fusion of the FAM49B and PREX2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FAM49B-PREX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| FAM49B-PREX2-20-AQAQ | 20 (40 μL) | 200 μL |
|
FAM49B Gene Summary
The Family With Sequence Similarity 49 Member B (FAM49B) gene is located on chr8 :130853715-130952000 at 8q24.21.
Gene Name: Family With Sequence Similarity 49 Member B
Chromosome: CHR8: 130853715 -130952000
Locus: 8q24.21
PREX2 Gene Summary
The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016]
Gene Name: Phosphatidylinositol-3,4,5-trisphosphate Dependent Rac Exchange Factor 2
Chromosome: CHR8: 68864602 -69143897
Locus: 8q13.2
Gene Diseases
The FAM49B PREX2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|