FAM19A4-UBA3 Fusion FISH Probe
The FAM19A4-UBA3 Fusion FISH Probe is used to confirm a fusion of the FAM19A4 and UBA3 genes. The fusion of the FAM19A4 and UBA3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FAM19A4-UBA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-RERE | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-REOR | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-REGO | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-REGR | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-REAQ | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-ORRE | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-OROR | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-ORGO | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-GORE | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-GOOR | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-GOGO | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-GOGR | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-GRRE | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-GROR | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-GRGO | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-GRGR | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-AQRE | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-AQOR | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-AQGO | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-AQGR | 20 (40 μL) | 200 μL |
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| FAM19A4-UBA3-20-AQAQ | 20 (40 μL) | 200 μL |
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UBA3 Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Like Modifier Activating Enzyme 3
Chromosome: CHR3: 69103880 -69129524
Locus: 3p14.1
FAM19A4 Gene Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like
Chromosome: CHR3: 68780916 -68981711
Locus: 3p14.1
Gene Diseases
The FAM19A4 UBA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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