FAM19A4-LMOD3 Fusion FISH Probe
The FAM19A4-LMOD3 Fusion FISH Probe is used to confirm a fusion of the FAM19A4 and LMOD3 genes. The fusion of the FAM19A4 and LMOD3 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FAM19A4-LMOD3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-RERE | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-REOR | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-REGO | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-REGR | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-REAQ | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-ORRE | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-OROR | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-ORGO | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-GORE | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-GOOR | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-GOGO | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-GOGR | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-GRRE | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-GROR | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-GRGO | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-GRGR | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-AQRE | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-AQOR | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-AQGO | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-AQGR | 20 (40 μL) | 200 μL |
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| FAM19A4-LMOD3-20-AQAQ | 20 (40 μL) | 200 μL |
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LMOD3 Gene Summary
The protein encoded by this gene is a member of the leiomodin family of proteins. This protein contains three actin-binding domains, a tropomyosin domain, a leucine-rich repeat domain, and a Wiskott-Aldrich syndrome protein homology 2 domain (WH2). Localization of this protein to the pointed ends of thin filaments has been observed, and there is evidence that this protein acts as a catalyst of actin nucleation, and is important to the organization of sarcomeric thin filaments in skeletal muscles. Mutations in this gene have been associated as one cause of Nemaline myopathy, as other genes have also been linked to this disorder. Nemaline myopathy is a disorder characterized by nonprogressive generalized muscle weakness and protein inclusions (nemaline bodies) in skeletal myofibers. Patients with mutations in this gene often present with a severe congenital form of the disorder. [provided by RefSeq, Jan 2015]
Gene Name: Leiomodin 3
Chromosome: CHR3: 69156038 -69171746
Locus: 3p14.1
FAM19A4 Gene Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like
Chromosome: CHR3: 68780916 -68981711
Locus: 3p14.1
Gene Diseases
The FAM19A4 LMOD3 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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