FAM104A-ACLY Fusion FISH Probe
The FAM104A-ACLY Fusion FISH Probe is used to confirm a fusion of the FAM104A and ACLY genes. The fusion of the FAM104A and ACLY genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FAM104A-ACLY-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-RERE | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-REOR | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-REGO | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-REGR | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-REAQ | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-ORRE | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-OROR | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-ORGO | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-ORAQ | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-GORE | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-GOOR | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-GOGO | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-GOGR | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-GOAQ | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-GRRE | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-GROR | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-GRGO | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-GRGR | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-GRAQ | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-AQRE | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-AQOR | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-AQGO | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-AQGR | 20 (40 μL) | 200 μL |
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| FAM104A-ACLY-20-AQAQ | 20 (40 μL) | 200 μL |
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ACLY Gene Summary
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
Gene Name: ATP Citrate Lyase
Chromosome: CHR17: 40023178 -40075272
Locus: 17q21.2
FAM104A Gene Summary
The Family With Sequence Similarity 104 Member A (FAM104A) gene is located on chr17 :71203491-71228533 at 17q25.1.
Gene Name: Family With Sequence Similarity 104 Member A
Chromosome: CHR17: 71203491 -71228533
Locus: 17q25.1
Gene Diseases
The FAM104A ACLY Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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