F11R-NOS1AP Fusion FISH Probe
The F11R-NOS1AP Fusion FISH Probe is used to confirm a fusion of the F11R and NOS1AP genes. The fusion of the F11R and NOS1AP genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| F11R-NOS1AP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-RERE | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-REOR | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-REGO | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-REGR | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-REAQ | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-ORRE | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-OROR | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-ORGO | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-ORAQ | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-GORE | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-GOOR | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-GOGO | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-GOGR | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-GOAQ | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-GRRE | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-GROR | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-GRGO | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-GRGR | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-GRAQ | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-AQRE | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-AQOR | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-AQGO | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-AQGR | 20 (40 μL) | 200 μL |
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| F11R-NOS1AP-20-AQAQ | 20 (40 μL) | 200 μL |
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NOS1AP Gene Summary
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
Gene Name: Nitric Oxide Synthase 1 Adaptor Protein
Chromosome: CHR1: 162039580 -162339813
Locus: 1q23.3
F11R Gene Summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
Gene Name: F11 Receptor
Chromosome: CHR1: 160965000 -160991133
Locus: 1q23.3
Gene Diseases
The F11R NOS1AP Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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