EZR-RB1CC1 Fusion FISH Probe
The EZR-RB1CC1 Fusion FISH Probe is used to confirm a fusion of the EZR and RB1CC1 genes. The fusion of the EZR and RB1CC1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EZR-RB1CC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-RERE | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-REOR | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-REGO | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-REGR | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-REAQ | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-ORRE | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-OROR | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-ORGO | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-GORE | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-GOOR | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-GOGO | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-GOGR | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-GRRE | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-GROR | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-GRGO | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-GRGR | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-AQRE | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-AQOR | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-AQGO | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-AQGR | 20 (40 μL) | 200 μL |
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| EZR-RB1CC1-20-AQAQ | 20 (40 μL) | 200 μL |
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EZR Gene Summary
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ezrin
Chromosome: CHR6: 159186772 -159240456
Locus: 6q25.3
RB1CC1 Gene Summary
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Gene Name: RB1 Inducible Coiled-coil 1
Chromosome: CHR8: 53535017 -53627026
Locus: 8q11.23
Gene Diseases
The EZR RB1CC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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