EZH2-AUTS2 Fusion FISH Probe
The EZH2-AUTS2 Fusion FISH Probe is used to confirm a fusion of the EZH2 and AUTS2 genes. The fusion of the EZH2 and AUTS2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EZH2-AUTS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-RERE | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-REOR | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-REGO | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-REGR | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-REAQ | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-ORRE | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-OROR | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-ORGO | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-GORE | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-GOOR | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-GOGO | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-GOGR | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-GRRE | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-GROR | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-GRGO | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-GRGR | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-AQRE | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-AQOR | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-AQGO | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-AQGR | 20 (40 μL) | 200 μL |
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| EZH2-AUTS2-20-AQAQ | 20 (40 μL) | 200 μL |
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EZH2 Gene Summary
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Gene Name: Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit
Chromosome: CHR7: 148504463 -148581441
Locus: 7q36.1
AUTS2 Gene Summary
This gene has been implicated in neurodevelopment and as a candidate gene for numerous neurological disorders, including autism spectrum disorders, intellectual disability, and developmental delay. Mutations in this gene have also been associated with non-neurological disorders, such as acute lymphoblastic leukemia, aging of the skin, early-onset androgenetic alopecia, and certain cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2014]
Gene Name: AUTS2, Activator Of Transcription And Developmental Regulator
Chromosome: CHR7: 69063905 -70257885
Locus: 7q11.22
Gene Diseases
The EZH2 AUTS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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