EZH1-MAP3K14 Fusion FISH Probe
The EZH1-MAP3K14 Fusion FISH Probe is used to confirm a fusion of the EZH1 and MAP3K14 genes. The fusion of the EZH1 and MAP3K14 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| EZH1-MAP3K14-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-RERE | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-REOR | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-REGO | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-REGR | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-OROR | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-GORE | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-GROR | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| EZH1-MAP3K14-20-AQAQ | 20 (40 μL) | 200 μL |
|
EZH1 Gene Summary
EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]
Gene Name: Enhancer Of Zeste 1 Polycomb Repressive Complex 2 Subunit
Chromosome: CHR17: 40852292 -40897071
Locus: 17q21.2
MAP3K14 Gene Summary
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 14
Chromosome: CHR17: 43340487 -43394414
Locus: 17q21.31
Gene Diseases
The EZH1 MAP3K14 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|