EYA4-PKIB Fusion FISH Probe
The EYA4-PKIB Fusion FISH Probe is used to confirm a fusion of the EYA4 and PKIB genes. The fusion of the EYA4 and PKIB genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EYA4-PKIB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-RERE | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-REOR | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-REGO | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-REGR | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-REAQ | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-ORRE | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-OROR | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-ORGO | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-ORAQ | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-GORE | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-GOOR | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-GOGO | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-GOGR | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-GOAQ | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-GRRE | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-GROR | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-GRGO | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-GRGR | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-GRAQ | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-AQRE | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-AQOR | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-AQGO | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-AQGR | 20 (40 μL) | 200 μL |
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| EYA4-PKIB-20-AQAQ | 20 (40 μL) | 200 μL |
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EYA4 Gene Summary
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Gene Name: EYA Transcriptional Coactivator And Phosphatase 4
Chromosome: CHR6: 133562494 -133853258
Locus: 6q23.2
PKIB Gene Summary
This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: CAMP-dependent Protein Kinase Inhibitor Beta
Chromosome: CHR6: 122793061 -123047518
Locus: 6q22.31
Gene Diseases
The EYA4 PKIB Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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