EXOC6B-CASP10 Fusion FISH Probe
The EXOC6B-CASP10 Fusion FISH Probe is used to confirm a fusion of the EXOC6B and CASP10 genes. The fusion of the EXOC6B and CASP10 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EXOC6B-CASP10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-RERE | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-REOR | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-REGO | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-REGR | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-REAQ | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-ORRE | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-OROR | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-ORGO | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-ORAQ | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-GORE | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-GOOR | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-GOGO | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-GOGR | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-GOAQ | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-GRRE | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-GROR | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-GRGO | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-GRGR | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-GRAQ | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-AQRE | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-AQOR | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-AQGO | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-AQGR | 20 (40 μL) | 200 μL |
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| EXOC6B-CASP10-20-AQAQ | 20 (40 μL) | 200 μL |
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CASP10 Gene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Gene Name: Caspase 10
Chromosome: CHR2: 202047620 -202094129
Locus: 2q33.1
EXOC6B Gene Summary
This gene encodes a protein which is a part of the evolutionarily conserved exocyst, a multimeric protein complex necessary for exocytosis, which in turn, is crucial for cell growth, polarity and migration. Disruption of this gene may be associated with phenotypes exhibiting multiple symptoms including intellectual disability and developmental delay (DD). [provided by RefSeq, Jun 2016]
Gene Name: Exocyst Complex Component 6B
Chromosome: CHR2: 72406443 -73053177
Locus: 2p13.2
Gene Diseases
The EXOC6B CASP10 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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