EXOC6-DTNB Fusion FISH Probe
The EXOC6-DTNB Fusion FISH Probe is used to confirm a fusion of the EXOC6 and DTNB genes. The fusion of the EXOC6 and DTNB genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EXOC6-DTNB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-RERE | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-REOR | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-REGO | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-REGR | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-REAQ | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-ORRE | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-OROR | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-ORGO | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-ORAQ | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-GORE | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-GOOR | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-GOGO | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-GOGR | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-GOAQ | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-GRRE | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-GROR | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-GRGO | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-GRGR | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-GRAQ | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-AQRE | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-AQOR | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-AQGO | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-AQGR | 20 (40 μL) | 200 μL |
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| EXOC6-DTNB-20-AQAQ | 20 (40 μL) | 200 μL |
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DTNB Gene Summary
This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]
Gene Name: Dystrobrevin Beta
Chromosome: CHR2: 25600111 -25896503
Locus: 2p23.3
EXOC6 Gene Summary
The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016]
Gene Name: Exocyst Complex Component 6
Chromosome: CHR10: 94594469 -94819251
Locus: 10q23.33
Gene Diseases
The EXOC6 DTNB Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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