EXOC4-PTAFR Fusion FISH Probe
The EXOC4-PTAFR Fusion FISH Probe is used to confirm a fusion of the EXOC4 and PTAFR genes. The fusion of the EXOC4 and PTAFR genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EXOC4-PTAFR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-RERE | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-REOR | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-REGO | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-REGR | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-REAQ | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-ORRE | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-OROR | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-ORGO | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-ORAQ | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-GORE | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-GOOR | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-GOGO | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-GOGR | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-GOAQ | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-GRRE | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-GROR | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-GRGO | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-GRGR | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-GRAQ | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-AQRE | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-AQOR | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-AQGO | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-AQGR | 20 (40 μL) | 200 μL |
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| EXOC4-PTAFR-20-AQAQ | 20 (40 μL) | 200 μL |
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PTAFR Gene Summary
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Platelet Activating Factor Receptor
Chromosome: CHR1: 28473676 -28520447
Locus: 1p35.3
EXOC4 Gene Summary
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Exocyst Complex Component 4
Chromosome: CHR7: 132937822 -133750513
Locus: 7q33
Gene Diseases
The EXOC4 PTAFR Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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