EXOC3-TAGLN Fusion FISH Probe
The EXOC3-TAGLN Fusion FISH Probe is used to confirm a fusion of the EXOC3 and TAGLN genes. The fusion of the EXOC3 and TAGLN genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EXOC3-TAGLN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-RERE | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-REOR | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-REGO | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-REGR | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-REAQ | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-ORRE | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-OROR | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-ORGO | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-ORAQ | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-GORE | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-GOOR | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-GOGO | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-GOGR | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-GOAQ | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-GRRE | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-GROR | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-GRGO | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-GRGR | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-GRAQ | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-AQRE | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-AQOR | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-AQGO | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-AQGR | 20 (40 μL) | 200 μL |
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| EXOC3-TAGLN-20-AQAQ | 20 (40 μL) | 200 μL |
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TAGLN Gene Summary
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]
Gene Name: Transgelin
Chromosome: CHR11: 117070039 -117075508
Locus: 11q23.3
EXOC3 Gene Summary
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]
Gene Name: Exocyst Complex Component 3
Chromosome: CHR5: 443333 -467409
Locus: 5p15.33
Gene Diseases
The EXOC3 TAGLN Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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