EXOC1-IDO1 Fusion FISH Probe
The EXOC1-IDO1 Fusion FISH Probe is used to confirm a fusion of the EXOC1 and IDO1 genes. The fusion of the EXOC1 and IDO1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EXOC1-IDO1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-RERE | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-REOR | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-REGO | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-REGR | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-REAQ | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-ORRE | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-OROR | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-ORGO | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-ORAQ | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-GORE | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-GOOR | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-GOGO | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-GOGR | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-GOAQ | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-GRRE | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-GROR | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-GRGO | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-GRGR | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-GRAQ | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-AQRE | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-AQOR | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-AQGO | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-AQGR | 20 (40 μL) | 200 μL |
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| EXOC1-IDO1-20-AQAQ | 20 (40 μL) | 200 μL |
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IDO1 Gene Summary
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
Gene Name: Indoleamine 2,3-dioxygenase 1
Chromosome: CHR8: 39771327 -39786309
Locus: 8p11.21
EXOC1 Gene Summary
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Exocyst Complex Component 1
Chromosome: CHR4: 56719815 -56771244
Locus: 4q12
Gene Diseases
The EXOC1 IDO1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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