EWSR1-ABR Fusion FISH Probe
The EWSR1-ABR Fusion FISH Probe is used to confirm a fusion of the EWSR1 and ABR genes. The fusion of the EWSR1 and ABR genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EWSR1-ABR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-RERE | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-REOR | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-REGO | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-REGR | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-REAQ | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-ORRE | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-OROR | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-ORGO | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-ORAQ | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-GORE | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-GOOR | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-GOGO | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-GOGR | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-GOAQ | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-GRRE | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-GROR | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-GRGO | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-GRGR | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-GRAQ | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-AQRE | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-AQOR | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-AQGO | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-AQGR | 20 (40 μL) | 200 μL |
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| EWSR1-ABR-20-AQAQ | 20 (40 μL) | 200 μL |
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ABR Gene Summary
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Active BCR-related
Chromosome: CHR17: 906758 -1090616
Locus: 17p13.3
EWSR1 Gene Summary
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
Gene Name: EWS RNA Binding Protein 1
Chromosome: CHR22: 29663997 -29696515
Locus: 22q12.2
Gene Diseases
The EWSR1 ABR Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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