EVPL-SRP68 Fusion FISH Probe
The EVPL-SRP68 Fusion FISH Probe is used to confirm a fusion of the EVPL and SRP68 genes. The fusion of the EVPL and SRP68 genes has been associated with Ovarian Serous Cystadenocarcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EVPL-SRP68-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-RERE | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-REOR | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-REGO | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-REGR | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-REAQ | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-ORRE | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-OROR | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-ORGO | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-ORAQ | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-GORE | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-GOOR | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-GOGO | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-GOGR | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-GOAQ | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-GRRE | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-GROR | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-GRGO | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-GRGR | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-GRAQ | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-AQRE | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-AQOR | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-AQGO | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-AQGR | 20 (40 μL) | 200 μL |
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| EVPL-SRP68-20-AQAQ | 20 (40 μL) | 200 μL |
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EVPL Gene Summary
This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016]
Gene Name: Envoplakin
Chromosome: CHR17: 74002926 -74023507
Locus: 17q25.1
SRP68 Gene Summary
This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
Gene Name: Signal Recognition Particle 68
Chromosome: CHR17: 74035190 -74068607
Locus: 17q25.1
Gene Diseases
The EVPL SRP68 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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